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以2-氯噻吩、多聚甲醛为原料,以离子液体[C2mim]Br、[C3mim]Br、[C4mim]Br、[C5mim]Br、[C6mim]Br、[C7mim]Br、[C8mim]Br、[C12mim]Br、[Bmim]PF6、[Bmim]BF4、[Bmim]C4F9SO3和[Bmim]Cl为催化剂进行氯甲基化反应,得到产物2-氯-3-氯甲基噻吩。研究表明,离子液体可以促进2-氯噻吩的氯甲基化反应,具有相转移催化剂的效果,并且以[C4mim]Br和[C8mim]Br的催化效果为佳。反应最佳条件为:离子液体[C8mim]Br摩尔分数为5%(相对于2-氯噻吩),温度40℃,反应时间8h,产物产率可达92.1%。
[C2mim] Br, [C3mim] Br, [C4mim] Br, [C5mim] Br, [C6mim] Br, [C7mim] Br, [C8mim] Br and 2-chlorothiophene with paraformaldehyde as raw materials. Chloromethylation of [C12mim] Br, [Bmim] PF6, [Bmim] BF4, [Bmim] C4F9SO3 and [Bmim] Cl gave the product 2-chloro-3- chloromethylthiophene. Studies have shown that ionic liquids can promote the chloromethylation reaction of 2-chlorothiophene, with the effect of phase transfer catalyst, and the catalytic effect of [C4mim] Br and [C8mim] Br is better. The optimum reaction conditions were as follows: the mole fraction of [C8mim] Br was 5% (relative to 2-chlorothiophene), the temperature was 40 ℃, the reaction time was 8h, the yield of product reached 92.1%.