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To examine vitamin D status in children with sickle cell disease (SCD)-SS and its relation to season and dietary intake. Growth, dietary intake, 25-hydroxyvitamin D (25-OHD), and parathyroid hormone levels were measured. Children with low and normal vitamin D status were compared. Low vitamin D status was defined as a serum concentration of 25-OHD < 27.5 nmol/L. Serum 25-OHD and parathyroid hormone levels were compared among children with SCD-SS and healthy children. Children with SCD-SS (n = 65), 5 to 18 years of age, were evaluated. Mean (± SD) serum 25-OHD concentration was 25.5 ± 12.8 nmol/L; 65% of subjects had low vitamin D status. Low vitamin D prevalence was highest during spring (100% ). Children with SCD-SS were at higher risk for low vitamin D status than healthy children. Vitamin D intake was lower in subjects with SCD-SS and low vitamin D than those with normal serum vitamin D status (P < .05). Low serum vitamin D status was highly prevalent in black children with SCD-SS. Vitamin D status was associated with season and dietary intake.
To examine vitamin D status in children with sickle cell disease (SCD) -SS and its relation to season and dietary intake. Growth, dietary intake, 25-hydroxyvitamin D (25-OHD), and parathyroid hormone levels were measured. and normal vitamin D status were compared. Low vitamin D status was defined as a serum concentration of 25-OHD <27.5 nmol / L. Serum 25-OHD and parathyroid hormone levels were compared among children with SCD-SS and healthy children. Children with Mean (± SD) serum 25-OHD concentration was 25.5 ± 12.8 nmol / L; 65% of subjects had low vitamin D status. Low vitamin D (n = 65), 5 to 18 years of age, prevalence was highest during spring (100%). Children with SCD-SS were at higher risk for low vitamin D status than healthy children. Vitamin D intake was lower in subjects with SCD-SS and low vitamin D than those with normal serum vitamin D status (P <.05). Low serum vitamin D status was highly prevalent in black children with SCD-SS . Vitamin D status was associated with season and dietary intake.