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小鼠分别腹腔内注射25～200mg/kg 西咪替丁或雷尼替丁后,再腹腔注射阈下催眠剂量戊巴比妥钠25mg/kg,西咪替丁可增加戊巴比妥钠的睡眠率,且与西咪替丁的剂量呈正比;而雷尼替丁则无明显影响。小鼠肝组织加入西咪替丁或雷尼替丁和戊巴比妥钠经37℃孵育后所得离心上清液给小鼠腹腔注射,西咪替丁和戊巴比妥钠孵育组睡眠率为90%;而雷尼替丁和戊巴比妥钠孵育组及生理盐水与戊巴比妥钠孵育组睡眠率均为0。提示,西咪替丁增强戊巴比妥钠催眠作用似通过抑制肝药酶产生。
Mice were intraperitoneal injection of 25 ~ 200mg / kg cimetidine or ranitidine, intraperitoneal injection of subliminal hypnosis dose of sodium pentobarbital 25mg / kg, cimetidine can increase the sodium pentobarbital Sleep rate, and the dose was proportional to cimetidine; while ranitidine had no significant effect. Mouse liver tissue by adding cimetidine or ranitidine and sodium pentobarbital after incubation at 37 ℃ obtained by centrifugation supernatant to mice intraperitoneal injection, cimetidine and pentobarbital sodium group sleep rate of sleep Was 90%; while the ranitidine and pentobarbital sodium incubation group and saline and pentobarbital sodium incubation group sleep rate was 0. Tip, cimetidine enhances pentobarbital sodium hypnotic effect through inhibition of hepatic drug production.