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目的:探讨Y染色体上AZF微缺失和反复自然流产之间的关系。方法:收集26份男性流产胚胎的绒毛样本,51份配偶反复流产的男性血液,分别提取基因组DNA,选取位于Yq11.2上AZFa、AZFb和AZFc的12个STS位点,对流产胚胎绒毛样本和血液样本进行AZF的多重PCR检测。结果:流产胚胎的26份样本中没有发现AZF的微缺失,51份血液样本中也没有发现AZF的微缺失。结论:排除AZF微缺失为反复自然流产的原因。
Objective: To investigate the relationship between AZF microdeletion on Y chromosome and recurrent spontaneous abortion. Methods: Twenty-six samples of aborted human fetus and 51 spouses of aborted male blood samples were collected and genomic DNA was extracted respectively. Twelve STS sites of AZFa, AZFb and AZFc on Yq11.2 were selected for abortion embryo villus samples and Blood samples were subjected to multiplex PCR detection of AZF. RESULTS: No microdeletion of AZF was detected in 26 samples of aborted embryos and no microdeletion of AZF was found in 51 blood samples. Conclusion: The reason of excluding AZF microdeletions is repeated spontaneous abortion.