患者袁××，男性，48岁，粮站保管员。患者鼻阻，鼻腔进行性溃烂，干痂多，分泌物臭已5年。曾先后多次在本院及重庆就医，诊断萎缩性鼻炎。于1985年初再次去重庆某医院检查诊断鼻中隔穿孔，伴肉芽组织增生。取中隔肉芽组织活检2次，病理报告为慢性炎症，副鼻窦摄片为多发性副鼻窦炎，血清康氏反应2次阴性。1985年3月患者发现硬腭穿孔，再次去重庆某医院检查，考虑穿孔 Patient × ×, male, 48 years old, grain stationkeeper. Patient nasal resistance, progressive nasal ulceration, dry scab and secretions smell has been 5 years. Has repeatedly in this hospital and Chongqing for medical treatment, diagnosis of atrophic rhinitis. In early 1985 once again to Chongqing, a hospital diagnosis of nasal septum perforation, with granulation tissue hyperplasia. Tissue biopsy septum taken 2 times, the pathological report of chronic inflammation, paranasal sinus radiography for multiple sinusitis, serum Kang’s reaction 2 negative. March 1985 patients found hard palate perforation, check again to a hospital in Chongqing, consider perforation