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目的探讨燃煤型氟中毒病区8~14岁儿童血清Ⅰ型胶原交联氨基末端肽(NTx)的浓度变化及其与年龄、氟斑牙程度的关系,为氟中毒骨性损伤研究提供人群数据资料。方法于2013年9月对贵州省187名8~14岁儿童(包括地方性氟中毒病区123人,对照区64人)进行氟斑牙诊断,并测定血清NTx浓度,分析病区不同氟斑牙程度的儿童血清NTx浓度变化及其与年龄、氟斑牙程度的相关性。结果燃煤型氟中毒病区儿童氟斑牙患病率为94.3%,高于对照区,差异有统计学意义(P<0.01);血清NTx浓度差异无统计学意义(P>0.05)。各年龄组病区儿童氟斑牙患病率均高于对照区,13~14岁病区儿童血清NTx浓度低于对照区,差异均有统计学意义(P<0.01)。氟斑牙轻度和中度组儿童的血清NTx浓度低于未患病和极轻度组,差异有统计学意义(P<0.05)。氟斑牙程度与年龄呈正相关(rs=0.377,P<0.05),与血清NTx浓度呈负相关(rs=-0.510,P<0.05),而血清NTx浓度与年龄无相关性(rs=-0.147,P>0.05)。结论过量的氟可能导致儿童血清NTx浓度降低,但其剂量-效应关系有待明确。
Objective To investigate the relationship between serum concentration of type Ⅰ collagen cross-linked amino-terminal peptide (NTx) and age and dental fluorosis in children aged 8-14 years in a coal-fluoridic fluorosis area, and to provide a basis for the study of bone damage in patients with fluorosis data. Methods A total of 187 children aged 8-14 years (including 123 in endemic fluorosis area and 64 in control area) were diagnosed with dental fluorosis in Guizhou Province in September 2013. Serum NTx levels were also measured. Change of NTx Concentration in Children with Tooth Degree and Its Correlation with Age and Degree of Dental Fluorosis. Results The prevalence rate of dental fluorosis in children with fluorosis poisoning was 94.3%, which was higher than that in the control group (P <0.01). There was no significant difference in serum NTx concentration between the two groups (P> 0.05). The prevalence of dental fluorosis in children in all age groups was higher than that in control group. The serum NTx levels in children aged 13-14 years were lower than those in control group (P <0.01). The level of serum NTx in children with mild and moderate dental fluorosis was significantly lower than that of non-diseased and mild mild (P <0.05). There was a positive correlation between dental fluorosis and age (rs = 0.377, P <0.05), but negatively correlated with serum NTx concentration (rs = -0.510, P <0.05) , P> 0.05). Conclusion Excessive fluoride may lead to the reduction of serum NTx concentration in children, but the dose-response relationship needs to be clarified.