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目的定量评价胆固醇侧链裂解酶基因(CYP11a)启动子(tttta)4、(tttta)6和(tttta)8微卫星多态性与多囊卵巢综合征(PCOS)发生的关联性及关联强度。方法制定原始文献的纳入和排除标准及检索策略。检索中外数据库,系统收集有关CYP11a多态性与PCOS相关性的研究报告,按照NOS标准对纳入文献进行质量评价。应用RevMan5.0软件对各文献进行异质性检验和Meta分析,得出合并后的OR值及其95%CI。结果共有8篇文献纳入Meta分析。数据合并结果显示,CYP11a启动子(tttta)6微卫星多态性与PCOS易感性之间关联性有统计学意义,OR值(95%CI)为0.75(0.59~0.95);(tttta)4和(tttta)8微卫星多态性与PCOS易感性之间关联性无统计学意义,OR值(95%CI)分别为0.89(0.61~1.30)和0.84(0.64~1.11)。结论 CYP11a启动子(tttta)6微卫星多态性是PCOS发病的保护因素,尚未见(tttta)4和(tttta)8微卫星多态性与PCOS发病风险之间的关联性。
OBJECTIVE: To quantitatively evaluate the association and correlation of the microsatellite polymorphisms of cholesterol side chain cleavage enzyme (CYP11a) promoter (tttta) 4, (tttta) 6 and (tttta) 8 in patients with polycystic ovary syndrome (PCOS). Methodology Development of inclusion and exclusion criteria and search strategies for original documents. Retrieve Chinese and foreign databases and systematically collect research reports on the association between CYP11a polymorphism and PCOS, and evaluate the quality of the included articles according to the NOS standard. Using RevMan5.0 software to heterogeneity and meta-analysis of each literature, the combined OR value and its 95% CI were obtained. Results A total of 8 articles were included in the meta-analysis. The data showed that the association between CYP11a promoter (tttta) 6 microsatellite polymorphism and susceptibility to PCOS was statistically significant (OR 95% CI 0.75 (0.59-0.95; tttta 4 and There was no significant correlation between tttta 8 microsatellite polymorphism and PCOS susceptibility. The odds ratio (95% CI) was 0.89 (0.61-1.30) and 0.84 (0.64-1.11), respectively. Conclusion CYP11a promoter (tttta) 6 microsatellite polymorphism is a protective factor in the pathogenesis of PCOS. There is no correlation between (tttta) 4 and (tttta) 8 microsatellite polymorphisms and the risk of developing PCOS.