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胰岛素样生长因子(IGF)家族存在于正常卵巢中,在细胞的增殖、分化和凋亡中起重要作用。越来越多的研究发现,IGF家族参与包括卵巢癌在内的众多恶性肿瘤的发生和发展。近年来对卵巢癌细胞和组织中IGF家族开展的大量研究结果显示,IGF家族可能在卵巢癌的转化和恶性进展中起重要作用,抑制其受体信号通路可能为卵巢癌的综合治疗提供新靶点。就IGF家族在卵巢癌领域的最新研究进展进行综述。
Insulin-like growth factor (IGF) family exists in the normal ovary and plays an important role in cell proliferation, differentiation and apoptosis. More and more studies have found that the IGF family is involved in the occurrence and development of many malignant tumors including ovarian cancer. In recent years, a large number of studies on IGF family in ovarian cancer cells and tissues have shown that IGF family may play an important role in the transformation and malignant progression of ovarian cancer. Inhibition of its receptor signaling pathway may provide a new target for the comprehensive treatment of ovarian cancer point. This review summarizes recent advances in the IGF family in the field of ovarian cancer.