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顺铂（ＤＤＰ）和顺式二水二氨合铂（Ⅱ）（ＡＡＰ）与人红细胞膜的相互作用已经用荧光及ＳＤＳＰＡＧＥ法研究，实验结果表明，ＤＤＰ和ＡＡＰ与人红细胞膜蛋白相互作用属双阶段一级反应动力学，而且ＡＡＰ的反应速率比ＤＤＰ大。ＳＤＳ－ＰＡＧＥ研究表明，ＤＤＰ和ＡＡＰ不仅可引起膜蛋白的交联或聚合，形成新带，也能使某些膜蛋白降解。对于ＤＤＰ，各膜蛋白带结合铂量首先随反应时间增加而下降，而后增加，最后达到饱和结合；ＡＡＰ与ＤＤＰ不同，各膜蛋白带结合铂量与反应时间的关系呈现复杂的变化，但长时间反应导致铂结合量降低。
The interaction of cisplatin (DDP) and cisplatin (Ⅱ) cisplatin (Ⅱ) with human erythrocyte membrane has been studied by fluorescence and SDSPAGE. The experimental results show that the interaction between DDP and AAP and human erythrocyte membrane protein is double Phase 1 reaction kinetics, and AAP reaction rate greater than DDP. SDS-PAGE studies show that DDP and AAP not only cause membrane protein cross-linking or polymerization, the formation of a new band, but also make some membrane protein degradation. For DDP, the amount of bound platinum in each membrane protein decreased first and then increased with the increase of reaction time, finally reached the saturation binding. Different from ADP and DDP, the relationship between the amount of bound platinum and the reaction time showed a complex change, Time response leads to a decrease in the amount of platinum bound.