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目的了解最近两年衢州地区急性腹泻患者中病毒的病原学分布特点。方法收集2011年-2012年衢州地区654例急性腹泻患者的粪便标本和流行病学资料,并进行腹泻相关病毒的多重RT-PCR和PCR检测。结果急性腹泻患者病毒检出率为19.11%(125/654),其中轮状病毒(RV)A型54例(8.26%)、C型3例(0.46%),诺如病毒(NV)GⅠ型6例(0.92%)、GⅡ型28例(4.28%),札如病毒(SAV)31例(4.74%),星状病毒(ADV)3例(0.46%);未检测到肠道腺病毒(ASV)。轮状病毒主要感染年龄为≥18岁,其他病毒在不同年龄组人群中感染率差异无统计学意义。轮状病毒发病高发期在11月至次年1月,杯状病毒的感染主要集中在2月-6月。结论衢州地区急性病毒性腹泻的病原复杂,杯状病毒是最主要病原。不同病种类病毒感染具有明显的季节性,制定防治策略时应予以重视。
Objective To understand the etiological distribution of virus in patients with acute diarrhea in Quzhou in the recent two years. Methods The stool samples and epidemiological data of 654 acute diarrhea patients in Quzhou area from 2011 to 2012 were collected. Multiplex RT-PCR and PCR were performed to detect the diarrhea-related viruses. Results The positive rate of virus in patients with acute diarrhea was 19.11% (125/654). Among them, 54 cases (8.26%) of rotavirus type A (RV), 3 cases (0.46%) of type C, 6 cases (0.92%), G Ⅱ type 28 cases (4.28%), Sapporo virus (SAV) 31 cases (4.74%) and Astrovirus (3 cases) ASV). The major infection age of rotavirus was ≥18 years old. The infection rates of other viruses in different age groups had no statistical significance. The incidence of rotavirus in the period from November to January next year, the main focus of calicivirus infection in February-June. Conclusion The pathogen of acute viral diarrhea in Quzhou is complex, and calicivirus is the most important pathogen. Different types of virus infection has obvious seasonal, prevention and control strategies should be given attention.