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目的了解结核病住院患者结核分枝杆菌耐药情况。方法收集2010年全年新收治结核病住院患者主要临床特征信息并进行统计分析,包括性别、年龄、糖尿病史、吸烟史及结核治疗史。回顾分析结核分枝杆菌临床分离株药敏试验结果。结果 2010年新分离分枝杆菌723株,其中结核复合群共671株,非结核分枝杆菌52株。671例结核病患者中,总耐药率43.82%、初治耐药率56.30%、复治耐药率32.07%;其中单耐药率、多耐药率和泛耐药率分别为13.41%、24.74%和5.66%。男女患者比例为2.2∶1,患者年龄最小8岁,最大88岁。女性患者患耐药结核病风险低于男性,OR值为0.63(95%CI:0.42~0.94),差异有统计意义(P<0.05)。结核病治疗史和吸烟史是患者发生耐药结核的危险因素,OR值分别为1.62(95%CI:1.21~2.09)和2.72(95%CI:2.35~3.05),差异有统计学意义(P均<0.05)。非结核分枝杆菌株检出量及其检出率逐年上升,检出率由2006年的4.61%上升到2010年的7.19%。结论应采取有效措施控制结核分枝杆菌感染及其耐药情况的进一步恶化。
Objective To understand the prevalence of Mycobacterium tuberculosis in hospitalized patients with tuberculosis. Methods The main clinical features of newly admitted tuberculosis patients in 2010 were collected and statistically analyzed, including gender, age, diabetes history, smoking history and tuberculosis treatment history. Retrospective analysis of clinical isolates of Mycobacterium tuberculosis susceptibility test results. Results A total of 723 new mycobacteria were isolated in 2010, of which 671 were tuberculosis complex and 52 were non-tuberculous mycobacteria. Among the 671 tuberculosis patients, the total drug resistance rate was 43.82%, the initial drug resistance rate was 56.30% and the retreatment rate was 32.07%. The single drug resistance rate, multidrug resistance rate and pan-drug resistance rate were 13.41% and 24.74 % And 5.66%. The ratio of male and female patients is 2.2: 1, the youngest patient is 8 years old and the oldest is 88 years old. The risk of developing drug-resistant tuberculosis in women was lower than that in men (OR = 0.63; 95% CI: 0.42-0.94). The difference was statistically significant (P <0.05). The treatment history of tuberculosis and the history of smoking were the risk factors for developing drug-resistant TB in the patients with odds ratios of 1.62 (95% CI: 1.21-2.09) and 2.72 (95% CI: 2.35-3.05), respectively <0.05). The detection rate and detection rate of non-tuberculosis mycobacteria strains increased year by year, the detection rate increased from 4.61% in 2006 to 7.19% in 2010. Conclusion Effective measures should be taken to control Mycobacterium tuberculosis infection and further deterioration of its drug resistance.