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目的 探讨甲基强的松龙冲击治疗儿童睡眠中癫痫性电持续状态（ES ES ）的疗效。方法 选取2007年5月至2013年4月在本院儿科门诊就诊的伴ES ES的癫痫患儿31例，随机分为治疗组和对照组，治疗组16例，对照组15例。治疗组给予甲基强的松龙冲击序贯泼尼松口服，并给予常规抗癫痫药物丙戊酸钠治疗。对照组给予丙戊酸钠口服治疗。随访6个月，并对结果进行分析。结果 治疗组16例患儿，有效12例，有效率75％，药物不良反应率25．7％，对照组15例，有效率46．6％，药物不良反应率22．8％。两组治疗有效率对比有显著性差异（P ＜0．05），两组药物不良反应率对比无显著性差异（P ＞0．05）。结论 甲基强的松龙冲击疗法对比常规抗癫痫药物，在治疗 ESES患儿上，效果明显，但须注意激素对患儿的不良反应。“,”Objective] To explore the efficacy of methylprednisolone pulse therapy for children with electrical status epilepticus in sleep(ESES) .[Methods]A total of 31 pediatric patients with epilepsy and ESES in pediatric outpatient de‐partment of our hospital from May 2007 to April 2013 were chosen and randomly divided into treatment group( n=16) and control group( n=15) .The treatment group was given methylprednisolone pulse therapy ,oral prednisone and con‐ventional antiepileptics valproate .The control group was only given oral valproate .All patients were followed up for 6 months .The results were analyzed .[Results]In treatment group ,12 patients were effective ,and the efficiency was 75% ,and the incidence of drug adverse reaction was 25 .7% .In control group ,15 patients were effective ,and the effi‐ciency was 46 .6% ,and the incidence of drug adverse reaction was 22 .8% .There was significant difference in the effi‐ciency between two groups( P0 .05) .[Conclusion]Compared with conventional antiepileptics ,methylprednisolone pulse therapy for pediatric patients with ESES has obvious efficacy ,but the side effect of hormone therapy on pediatric patients should be paid attention .