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奥曲肽(Dctreotide),又称善得定(sandostatin,即SMS201—995),是一个以生长抑素(somatostatin,SS)活性片段为骨架合成的环形八肽,即为SS的类似物。本文就其降低门脉高压的作用特点及在食管静脉曲张破裂出血中应用现状综述如下。 1 作用特点 奥曲肽于1982年由Bauer等合成,对恒河猴应用后发现,该药对胰岛素和胰高血糖素释放的抑制较SS分别高1.3倍和11倍。首次静脉注射半衰期约10分钟,再次用药达80分钟,皮下注射半衰期1～2小时,生物利用度80％～135％,约65％与血
Dictreotide, also known as sandostatin (SMS201-995), is a cyclic octapeptide synthesized from the active fragment of somatostatin (SS), which is an analogue of SS. This article on its role in reducing the role of portal hypertension and esophageal variceal bleeding in the current status of the application are summarized below. 1 Features octreotide was synthesized by Bauer et al in 1982, the application of rhesus monkeys found that the drug on insulin and glucagon release were 1.3 times and 11 times higher than the SS. The first intravenous half-life of about 10 minutes, once again for 80 minutes, subcutaneous half-life of 1 to 2 hours, bioavailability of 80% to 135%, about 65% and blood