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研究证实胃肠组织化生,特别是胃小弯处化生引致的胃粘膜萎缩是胃癌发病的高风险标记。该项研究还提示血清中的胃泌素17和胃蛋白酶原Ⅰ的联合检测可鉴别高危胃癌发病个体。来自于日本 Wakayama 大学的 Akiko Shiotani 博士及其同事设计此项试验以通过组织学和血清生物学标记物筛查胃癌发生或发展的高危患者人群。试验中,研究人员对内窥镜下粘膜切除术后的53例早期非贲门性胃癌患者和75例接受窥镜胃溃疡随访或健康检查的75例幽门螺旋杆菌阳性对照者分别进行胃窦和胃体组织学、胃蛋白酶原Ⅰ和胃泌素17的血清浓度的检测对比研究。Shiotani 研究小组在近期的《国际癌症杂志》上刊文指出,与对照组患者相比,胃癌患者的胃部各区域内的肠组织化生和胃小弯处萎缩的评分均明显较高,其中胃部炎症与患者增加的3.4倍胃癌发病率相关联;胃小弯处的肠组织化生与15.1倍的胃癌患病率相关联;因此可作为胃癌发病最重要的风险标记物。此外,研究人员强调指出,胃大弯处的
Study confirmed that gastrointestinal metaplasia, especially gastric mucosal atrophy caused by metaplasia is a high-risk marker of gastric cancer. The study also suggested that the combined detection of serum gastrin 17 and pepsinogen I could identify individuals at high risk of developing gastric cancer. Akiko Shiotani, Ph.D., from Wakayama University in Japan and colleagues designed the trial to screen high-risk patient populations for the development or progression of gastric cancer through histological and serum biomarkers. In the study, the researchers conducted 53 cases of early noncardia gastric cancer after endoscopic mucosal resection and 75 cases of Helicobacter pylori positive control who underwent follow-up or medical examination of endoscopic gastric ulcer. Histological examination, comparison of serum concentrations of pepsinogen Ⅰ and gastrin 17. Shiotani research group in the recent “International Journal of Cancer,” published an article that compared with patients in the control group, gastric cancer in all regions of the stomach intestinal metaplasia and gastric atrophy scores were significantly higher, of which Gastric inflammation is associated with an increased 3.4-fold incidence of gastric cancer in patients; intestinal metaplasia of the small bends is associated with a 15.1-fold higher prevalence of gastric cancer; and therefore may be the most important risk marker for the development of gastric cancer. In addition, the researchers emphasized that the stomach had a large curvature