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目的通过分析结肠癌中Ang-2蛋白表达与结肠癌病理因素的关系,探讨Ang-2蛋自在结肠癌发生中的临床意义。方法用S-P免疫组化法检测31例结肠癌中Ang-2蛋白表达情况,并用SPSS10．0 for Windows软件统计分析Ang-2与临床病理因素的关系。以20例溃疡性结肠炎,21例结肠腺瘤和10例正常结肠黏膜作为对照组。结果结肠癌中Ang-2蛋白表达阳性率明显高于正常结肠黏膜组织(P(0．05),从溃疡性结肠炎、结肠腺瘤到结肠癌中Ang-2蛋白表达阳性率不同且具有递增趋势。Ang-2蛋白表达与结肠癌的 Duke’s分期及有无淋巴结转移显著相关(P<0．05)。结论 Ang-2蛋白过度表达在结肠癌发生中具有一定的临床意义。
Objective To investigate the clinical significance of angiopoietin-2 (Ang-2) in the development of colon cancer by analyzing the relationship between Ang-2 protein and pathological factors in colon cancer. Methods The expression of Ang-2 protein in 31 cases of colon cancer was detected by S-P immunohistochemistry. The relationship between Ang-2 and clinicopathological parameters was analyzed by SPSS 10.0 for Windows software. 20 cases of ulcerative colitis, 21 cases of colon adenoma and 10 cases of normal colon mucosa as a control group. Results The positive rate of Ang-2 protein expression in colorectal cancer was significantly higher than that in normal colorectal mucosa (P <0.05). The positive rates of Ang-2 protein expression in ulcerative colitis and colorectal adenoma were different (P <0.05) .Conclusion Ang-2 protein overexpression has some clinical significance in the development of colon cancer.