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已有40多篇关于精神分裂症病人和正常对照者的血小板MAO活性与诊断及精神病理关系的报导。Murphy和Wyatt报告,慢性精神分裂症病人血小板MAO活性降低。此后许多报告认为这是由于病人服神经松弛剂后人为地引起血小板MAO活性降低。但是,Murphy等在其后的报告指出精神分裂症病人服神经松弛剂后,少数人的血小板MAO活性却是增加的。另一由Potkin报导的结果是切除神经松弛剂后对血小板MAO活性无影响。本文研究病人在服神经松弛剂后血小板MAO活性的变化,结果是减低的。
More than 40 articles on the relationship between platelet MAO activity and diagnosis and psychopathology in schizophrenia patients and normal controls have been reported. Murphy and Wyatt report reduced platelet MAO activity in patients with chronic schizophrenia. Since then, many reports suggest that this is due to the fact that the patient induced a decrease in platelet MAO activity after taking a neuroleptic agent. However, Murphy and coworkers reported an increase in platelet MAO activity in a minority of individuals after subsequent reports of schizophrenia patients with neuroleptic agents. Another report by Potkin results in no effect on platelet MAO activity after nerve blocker excision. This article studies patients with neuroleptics after platelet MAO activity changes, the result is reduced.