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高胆红素血症是新生儿期最常见症状之一，本研究探讨了感染性黄疸和非感染性黄疸与细胞因子──肿瘤坏死因子α（TNFα）、白细胞介素6（IL-6）和白细胞介素8（IL-8）的关系。结果显示感染性黄疸患儿的IL-6，TNFα均极显著高于非感染性患儿组（P＜0．01），TL-8的水平显著高于非感染组（P＜0．05），表明感染性黄疸患儿机体免疫系统产生了积极反应，上述细胞因子均参与了机体的炎症反应过程，而IL-8的产生没有IL-6和TNFα升高显著，可能与IL-8主要参与局部炎症反应有关。提示感染性黄疸患儿血清中上述细胞因子显著增高时，可指导临床积极预防核黄疸发生。
Hyperbilirubinemia is one of the most common symptoms in neonatal period. This study explored the relationship between infectious jaundice and noninfectious jaundice and cytokines such as tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6) And interleukin-8 (IL-8). The results showed that the levels of IL-6 and TNFα in children with infectious jaundice were significantly higher than those in non-infected children (P <0.01), TL-8 was significantly higher than those in non-infected group (P0.05) , Indicating that the infectious immune jaundice in children with a positive response to the body’s immune system, the above cytokines are involved in the body’s inflammatory response process, and IL-8 production of IL-6 and TNFα increased significantly, may be associated with the main IL-8 Local inflammatory response. Tip Infectious jaundice in serum of the above cytokines significantly increased, can guide the clinical active prevention of nuclear jaundice.