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治疗性疫苗主要是通过打破机体的免疫耐受,提高机体的特异性免疫反应,对一些目前尚无有效治疗药物的疾病起到治疗作用。它不仅具有传统疫苗的一般功能,而且能够用于临床患者的治疗,因此治疗性疫苗研究近年来得到了很大的发展,临床数据表明治疗性疫苗在肿瘤、高血压和乙型肝炎等慢性复发性感染等疾病方面具有不同程度的疗效。现从治疗性疫苗的概念以及与传统疫苗的比较、作用机制、研究应用等方面进行介绍。
Therapeutic vaccine mainly through the body to break the immune tolerance, enhance the body’s specific immune response, for some currently no effective treatment of diseases play a therapeutic effect. It not only has the general function of traditional vaccines, but also can be used in the treatment of clinical patients. Therefore, therapeutic vaccine research has been greatly developed in recent years. Clinical data show that the therapeutic vaccine has long-term recurrence in tumors, hypertension and hepatitis B Infection and other diseases have varying degrees of efficacy. Now the concept of therapeutic vaccines and the comparison with traditional vaccines, mechanism of action, research applications and so on are introduced.