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目的 探讨胎儿宫内生长迟缓 (intrauterinegrowthretardation ,IUGR)时母血、脐血、羊水及胎盘组织中内皮素 1(ET 1)水平与IUGR发病的关系。方法 12例IUGR孕妇 ,10例正常孕妇 ,取母血、脐血及胎盘组织 ,用放射免疫法测其ET 1水平。结果 IUGR组胎盘ET 1水平明显高于正常组 ,差异极显著 (P <0 .0 1) ,两组间母血、脐血、羊水中的ET 1水平无差异。两组胎盘ET 1均明显高于母血、脐血、羊水 (P <0 .0 5 ) ,正常组母血、脐血、羊水ET 1水平差异无显著性。结论 胎盘组织中ET 1过高可与IU GR发病有关。
Objective To investigate the relationship between endothelin 1 (ET 1) levels and the incidence of IUGR in maternal blood, cord blood, amniotic fluid and placenta during intrauterine growth retardation (IUGR). Methods Twelve IUGR pregnant women and 10 normal pregnant women received maternal blood, umbilical cord blood and placental tissue. The levels of ET 1 were measured by radioimmunoassay. Results The level of ET 1 in placenta of IUGR group was significantly higher than that in normal group (P <0.01). There was no difference in ET 1 level between maternal blood, umbilical cord blood and amniotic fluid. ET 1 in both groups was significantly higher than that in maternal blood, umbilical cord blood and amniotic fluid (P <0.05). There was no significant difference in ET 1 levels between the two groups in maternal blood, umbilical cord blood and amniotic fluid. Conclusion The high level of ET 1 in placenta may be related to the pathogenesis of IU GR.