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气管插管是呼吸道传染病独立的感染危险因素。回顾性分析正压过滤头罩、三级防护下，12例新型冠状病毒肺炎患者气管插管的麻醉、插管方法、并发症，以及9名参加操作医务人员之后14 d的体温和核酸检测结果。在咪达唑仑+丙泊酚+吗啡/芬太尼镇静镇痛、麻醉下，12例患者均顺利、成功地在支气管镜引导下完成气管插管，未出现严重并发症。9名医务人员均未出现发热，咽拭子核酸检测阴性。新型冠状病毒肺炎患者气管插管时，医务人员在正压过滤头罩、三级防护下，没有出现感染，佩戴防护用品可安全、顺利完成操作。“,”Endotracheal intubation is an independent risk factor for respiratory infectious diseases. We conducted a retrospective study in 12 cases with COVID-19 who underwent endotracheal intubation at ICU of the Guangzhou eighth hospital from January 20 to February 10, 2020. The intubation procedure, anesthetic regimen, and complication were collected and analyzed. The 9 healthcare workers who involved in intubation received virus nucleic acid test and 14 days temperature monitoring. All 12 patients were successfully intubated under the guidance of bronchoscope, without any complications. Midazolam, Propofol and Morphine or fentanyl were used for sedation and analgesia, avoiding patients cough and agitated during the procedure. The 9 healthcare workers were protected under the Personal Protective Equipment(PPE) with positive pressure protective hood. The detection of oropharyngeal swab virus nucleic acid were negative in all 9 healthcare workers, none of them had fever or any respiratory symptoms. The PPE with positive pressure protective hood should be needed to perform bronchoscope-guided endotracheal intubation in patients with COVID-19, it could strengthen to protect healthcare workers from virus exposure.