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目的探讨左乙拉西坦添加治疗对部分性癫患者认知及生活质量的影响。方法选取2011-01—2012-06就诊于本院神经内科的部分性癫患者40例,按照随机对照原则分为观察组和对照组,每组各20例。在常规治疗基础上,观察组患者加用左乙拉西坦治疗,对照组给予安慰剂治疗。治疗6个月,对2组患者的认知及生活质量情况进行比较。结果 (1)治疗6个月后,观察组治疗有效率高于对照组,差异有统计学意义(χ2=8.64,P<0.01);(2)左乙拉西坦添加治疗6个月后,在对发作的担心、精力/疲乏、认知、药物影响、社会功能及生活质量总分均高于对照组,差异有统计学意义(P<0.05)。结论左乙拉西坦添加治疗部分性癫发作,可有效减少发作次数,提高患者的生活质量,改善患者的认知。
Objective To investigate the effects of levetiracetam on cognition and quality of life in patients with partial epilepsy. Methods Forty patients with partial epilepsy admitted to our department of neurology from January 2011 to June 2012 were divided into observation group and control group according to randomized control principle, with 20 cases in each group. On the basis of routine treatment, the observation group plus levetiracetam treatment, the control group were given placebo treatment. Treatment for 6 months, two groups of patients with cognitive and quality of life were compared. Results (6) After 6 months treatment, the effective rate of observation group was higher than that of control group (χ2 = 8.64, P <0.01); (2) After 6 months of treatment with levetiracetam, The total score of worry about anxiety, energy / fatigue, cognition, drug influence, social function and quality of life were all higher than that of the control group, the difference was statistically significant (P <0.05). Conclusion Levetiracetam added for the treatment of partial epileptic seizures, can effectively reduce the number of attacks, improve patient quality of life, improve patient awareness.