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目的探讨 MR 氢质子波谱(~1H-MRS)技术定量检测脂肪肝的可行性。方法对20例脂肪肝患者及11例健康志愿者行 CT 平扫、常规 MR 扫描及~1H-MRS 检查,所有脂肪肝患者 MR 检查当天均行血清肝功能检查。~1H-MRS 测量水和脂质波峰峰值和波峰下面积,计算脂质相对含量,并比较其与 CT 检查结果及肝功能各指标的一致性。结果正常组及脂肪肝组 CT 值分别为:(59±9)、(24±11)HU,正常组 MRS 可见明显高耸的水峰及低平的脂质峰,脂肪肝组可见明显高耸的水峰及低于水峰的脂质峰。正常组及脂肪肝组脂质峰峰值分别为:(0.05±0.01)×10~5、(0.70±0.24)×10~5(t=4.32,P<0.05),水峰峰值分别为(1.80±0.52)×10~5、(1.85±0.47)×10~5(t=1.26,P>0.05);脂肪峰值下面积分别为:(1.36±0.73)×10~9、(2.35±1.15)×10~9(t=5.21,P<0.05),水峰峰值下面积分别为(4.33±1.28)×10~(11)、(3.55±0.94)×10~(11)(t=2.04,P>0.05)。结论 ~1H-MRS 技术定量检测脂肪肝是可行的,而且是一种非创伤性早期定量检测脂肪肝的方法。
Objective To investigate the feasibility of quantitative detection of fatty liver by MR hydrogen proton spectroscopy (~ 1H-MRS). Methods Twenty patients with fatty liver and 11 healthy volunteers underwent CT scan, routine MR scan and ~ 1H-MRS. All patients with fatty liver underwent liver function tests on the day of MR examination. ~ 1H-MRS measurement of water and lipid peak area and area under the peak, calculate the relative content of lipids, and compare with the CT findings and liver function of the indicators of consistency. Results The CT values of the normal group and the fatty liver group were (59 ± 9) and (24 ± 11) HU, respectively. Significantly higher peak and lower lipid peak were observed in the MRS of normal group. Peaks and lipid peaks below water peak. The lipid peak of normal group and fatty liver group were (0.05 ± 0.01) × 10 ~ 5, (0.70 ± 0.24) × 10 ~ 5 (t = 4.32, (1.36 ± 0.73) × 10 ~ 9, (2.35 ± 1.15) × 10 (P <0.05). The area under the peak area of fat were 0.52 × 10 ~ 5 and 1.85 ± 0.47 × 10 ~ (T = 2.04, P> 0.05). The area under the peak of water peak was (4.33 ± 1.28) × 10 ~ (11), (3.55 ± 0.94) × 10 ~ (11) ). Conclusion ~ 1H-MRS is a feasible method for the quantitative detection of fatty liver, and it is a noninvasive and early quantitative method to detect fatty liver.