自从δ，μ，κ阿片受体的氨基酸序列被确定下来后，一种新的阿片受体样受体 Ｏ Ｒ Ｌ 在１９９４ 年被克隆出来，它与经典阿片受体高度同源。次年，找到了这种受体的内源性配体 Ｏ Ｆ Ｑ，它与强啡肽 Ａ 的化学结构高度相似。本文综述这种新的受体／ 配体在神经功能方面作用的研究进展。 Since the amino acid sequence of the δ-, μ-and κ-opioid receptors has been determined, a novel opioid receptor-like receptor, O R L, was cloned in 1994 and is highly homologous to classical opioid receptors. The following year, the endogenous ligand for this receptor, O F Q, was found that is highly similar to the chemical structure of dynorphin A. This article reviews the recent advances in the role of this new receptor / ligand in neurological function.