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肝癌的癌变机理,是研究肝癌的一个重要课题。许多学者曾用二乙基亚硝胺(DEN)、N-2-乙酰氨基芴(2-AAF)、奶油黄(3′-Me-DAB)等化学致癌剂对大鼠进行诱癌,并观察肝癌形成过程中的病理变化,但在流行病学调查中,此类致癌剂与人类肝癌发生尚无明确关系。自Lancaster(1961)等首先发现黄曲霉毒素(AFT)的致癌作用以来,AFT和肝癌关系为人们所重视。我国肝癌高发区启东、扶绥等地的的流行病学调
The mechanism of canceration of liver cancer is an important issue for studying liver cancer. Many scholars have used cancer-causing carcinogens such as diethylnitrosamine (DEN), N-2-acetylaminoanthraquinone (2-AAF) and cream yellow (3’-Me-DAB) to induce cancer in rats and observe Pathological changes in the formation of liver cancer, but in epidemiological investigations, there is no clear relationship between such carcinogens and human liver cancer. Since Lancaster (1961) first discovered the carcinogenic effects of aflatoxin (AFT), the relationship between AFT and liver cancer has been valued by people. Epidemiological adjustment of Qidong, Fusui and other places with high incidence of liver cancer in China