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介绍了美国环境保卫基金会资深科学家理查德·丹尼森提出的《有毒物质控制法改革十要素》以及美国化学理事会专家针对有毒物质控制法改革提出的5项建议,概述了由参议员弗兰克·劳滕伯格提出的作为有毒物质控制法改革最受瞩目的提案法规即美国化学品安全法案的主要内容及其特色,从安全数据要求、证据举证、安全评估、评估范围、高关注化学品及其暴露、管制行动、信息途径、规则制定要求等8方面比较分析了有毒物质控制法和化学品安全法案的区别.“,”“Ten essential elements in Toxic Substances Control Act(TSCA) reform” proposed by senior scientist Richard A. Denison in Environmental Defense Fund,five suggestions proposed by experts of American Chemistry Council on the reform of TSCA were introduced respectively.And the most focused substitute for TSCA,Safe Chemicals Act introduced by Senator Frank R. Lautenberg were summarized. Further the differences of TSCA and the Safe Chemicals Act was compared and analyzed from eight aspects,the study of safety data,burden of proof,assessment of safety,scope of assessment,chemicals and exposures of high concern,regulation action,information access and rulemaking requirement.