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迄今为止,尚未找到既安全又有效的治疗矽肺的药物。本文报道了中药丹参对染石英尘大鼠肺纤维化发生发展的影响。材料和方法选用健康雄性Wistar系大鼠,体重250g左右,随机分为3组:(1)正常对照组;(2)石英尘组;(3)丹参组。采用非暴露式气管注入法染尘,后2组每只动物注入标准石英粉尘(中国预防医学科学院提供)40mg。对照组给予同量生理盐水,丹参组在染尘后次日,皮下注射给药,
To date, no safe and effective drug for the treatment of silicosis has been found. This article reports the effect of Salvia miltiorrhiza on the occurrence and development of pulmonary fibrosis in rats exposed to quartz. Materials and Methods Healthy male Wistar rats weighing 250 g were randomly divided into three groups: (1) normal control group; (2) quartz dust group; (3) Salvia miltiorrhiza group. Non-exposed endotracheal intubation was used to infect the dust. Two animals in each group were injected with 40 mg of standard quartz dust (provided by the Chinese Academy of Preventive Medicine). The control group was given the same amount of saline, Salvia group dyed the next day after subcutaneous injection,