多柔比星是治疗乳腺癌、肺癌的1种有效的化疗药物。现存的主要问题是临床使用时肿瘤细胞产生多药耐药。为克服多药耐药,研究者们报道了一些利用纳米载药系统传递多柔比星的方法。纳米载药系统生物相容性好,稳定性高,具有药物控释和靶向性的优点,在药物传递中应用广泛。纳米载药系统可分为无机物纳米系统、基于脂质的纳米系统和聚合物纳米系统3种类型,在多柔比星载药中均有应用。综述近年来有关纳米载药系统最新研究文献,对其研究进展作了分析,并展望了其发展前景。 Doxorubicin is an effective chemotherapy drug for the treatment of breast cancer and lung cancer. The main existing problem is multidrug resistance of tumor cells in clinical use. To overcome multi-drug resistance, researchers report several ways to deliver doxorubicin using nanocarrier systems. Nanophase drug delivery system with good biocompatibility, high stability, with controlled release of drugs and the advantages of targeting, widely used in drug delivery. Nanophase drug delivery system can be divided into inorganic nano-systems, lipid-based nano-systems and polymer nano-systems of three types, are used in the drug doxorubicin. In this paper, the latest research literature on nanophase drug delivery systems in recent years is reviewed, and the progress of the research is also analyzed. The development prospects of the system are also prospected.