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目的:将糖适平与中效胰岛素联合应用于继发性磺脲药失效的2型糖尿病患者,以探讨其临床应用价值。方法:40 例入院诊断为磺脲药继发性失效的2型糖尿病患者,先予早晚注射中效胰岛素治疗,对其中30例空腹血糖(FBG)<7．8 mmol ·L-1,餐后2h血糖仍大于11．1 mmol·L-1的患者,给予3餐前口服糖适平,观察餐后血糖变化。结果:经糖适平治疗,平均餐后血耱(PBG)由13．6±2．6 mmol·L-1降至7．2±3．7 mmol·L-1,有统计学差异。结论:对磺脲药失效患者采用中效胰岛素与糖适平联合应用,可使空腹及餐后血糖得到良好控制。
OBJECTIVE: To investigate the clinical value of glycyrrhizin combined with moderate-acting insulin in type 2 diabetic patients with secondary sulfonylurea failure. Methods: Forty patients with type 2 diabetes mellitus diagnosed as secondary failure of sulfonylurea were treated with fasting insulin injection, 30 cases of which had fasting blood glucose (FBG) <7.8 mmol · L-1, 2h blood glucose is still greater than 11.1 mmol·L-1 patients, given 3 meals before oral glucose level, observed postprandial blood glucose changes. Results: The mean postprandial blood meal (PBG) decreased from 13.6 ± 2.6 mmol·L-1 to 7.2 ± 3.7 mmol·L-1 with the glucose-lowering therapy, with statistical significance. CONCLUSIONS: The fasting and postprandial blood glucose can be well controlled by the combination of moderate-acting insulin and glycyrrhizin in patients with failure of sulfonylurea.