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在有丝分裂中期染色体中检测姐妹染色单体交换(SCE)可作为生殖毒理学和诱变性测试系统的一部分,并可作为细胞损害的一个灵敏指标。SCE可能与细胞 DNA 合成、损伤、修复有关,SCE 的检测是检验诱变剂和致癌物质的有用方法。已知许多环境因素可增加 SCEs 的频率,其中影响最大的是双功能烷化剂,如丝裂霉素 C。其它环境因素有物理的、化学的及病毒感染。遗传因素亦与 SCE频率有关。本研究讨论 SCE 水平和生育情况的相关性。
Detection of sister chromatid exchange (SCE) in metaphase chromosomes can be used as part of reproductive toxicology and mutagenicity testing systems and can be used as a sensitive indicator of cellular damage. SCE may be related to cell DNA synthesis, injury, repair, SCE detection is a useful method to test mutagens and carcinogens. Many environmental factors are known to increase the frequency of SCEs, the most influential of which are bifunctional alkylating agents such as mitomycin C. Other environmental factors are physical, chemical and viral infections. Genetic factors are also related to the frequency of SCE. This study discusses the correlation between SCE levels and fertility.