许多抗菌素能改变真核细胞(Eukaryotic cells)的细胞膜的通透性。两性霉素B能促进第二种药物进入真菌和动物细胞,从而增强了第二种药物的作用。作者应用二种对细胞膜有作用的抗菌素两性霉素B和多粘菌素B,观察它们增强利福平、利福平类似物和四环素对于小鼠L-细胞和人体KB细胞及HeLa细胞的作用。细胞采用旋转培养法。分别在加入或不 Many antibiotics alter the membrane permeability of eukaryotic cells. Amphotericin B enhances the second drug’s effect by boosting the second drug into fungal and animal cells. The authors applied two antibiotics, amphotericin B and polymyxin B, which have an effect on cell membranes and observed their effects on the growth of mouse L-cells and human KB cells and HeLa cells by rifampicin, rifampin analogs and tetracycline . The cells are cultured by rotary culture. Respectively, with or without