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目的 :探讨转化生长因子 β1(TGF β1)及其Ⅱ型受体 (TβRⅡ )在喉癌中的表达情况及其生物学意义。方法 :采用免疫组化SP法对 5 3例喉癌和 4 8例癌旁组织中TGF β1、TβRⅡ的表达情况进行检测。结果 :喉癌TGF β1的表达明显低于癌旁组织 (P <0 .0 5 )。TβRⅡ的表达与癌旁组织对照差异无显著性意义 (P >0 .0 5 ) ,但与肿瘤组织分化程度、临床分期和淋巴结转移密切相关。结论 :TGF β1和TβRⅡ参与调控喉癌的发生、发展和转移过程 ,TGF β1和TβRⅡ是监测喉癌的有用指标。
Objective: To investigate the expression of transforming growth factor β1 (TGFβ1) and its type Ⅱ receptor (TβRⅡ) in laryngeal carcinoma and its biological significance. Methods: The expressions of TGFβ1 and TβRⅡ in 53 cases of laryngeal carcinoma and 48 cases of para-carcinoma tissues were detected by immunohistochemical SP method. Results: The expression of TGF-β1 in laryngeal carcinoma was significantly lower than that in paracancerous tissues (P <0.05). The expression of TβRⅡwas not significantly different from that of adjacent normal tissues (P> 0.05), but closely correlated with the degree of differentiation, clinical stage and lymph node metastasis. CONCLUSION: TGFβ1 and TβRII are involved in the regulation of carcinogenesis, development and metastasis of laryngeal carcinoma. TGFβ1 and TβRII are useful indicators for monitoring laryngeal carcinoma.