论文部分内容阅读
本文作者对用氨甲喋呤、羟基脲和阿扎利宾(Azaribine)治疗银屑病10年之经验进行了总结。使用这些细胞毒性药物的指征是:(1)威胁生命的或造成严重残废的疾病;(2)可逆的损害;(3)对常规治疗失败,或有不可耐受的副作用;(4)无活动性感染;(5)无血液学的禁忌症,等等。所有患者,除因症状有显著改善而较早停药,或因严重的副作用而被迫停药者外,都接受了至少6周的积极治疗。氨甲喋呤: 共治疗246例,应用方法有下述4种:①开始剂
The authors conclude 10 years of experience with methotrexate, hydroxyurea and azaribine in the treatment of psoriasis. Indications for the use of these cytotoxic drugs are: (1) life-threatening or severe disabling conditions; (2) reversible damage; (3) failure to treat routinely or intolerable side effects; (4) Active infection; (5) Hematology-free contraindications, and more. All patients received active treatment for at least 6 weeks except for those who discontinued earlier due to a significant improvement in their symptoms or were discontinued due to severe side effects. Methotrexate: a total of 246 cases of treatment, there are four methods of application: ① start agent