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目的 探讨抗小细胞肺癌单克隆抗体99Tcm 2F7F(ab′) 2 放射免疫显像对肺癌诊断的可行性及用药安全性。方法 1 8例肺癌患者静脉注射99Tcm 2F7F(ab′) 2 1～ 2mg约 1 1 1 0MBq ,7～ 8h后行胸部平面前后位及断层显像 ,2 4h再行平面显像。显像结果与X线胸片对照 ,以病灶区与正常对照区的计数比 (T/N) >1 .2为阳性。结果 1 8例患者从注药到显像结束以及随后的随访均未发现任何不良反应。未经治疗或正在化疗的小细胞肺癌患者 9例显像均呈阳性 ;化疗超过 1 0d或多次化疗者计 5例 ,4例显像阳性 ,临床均为治疗效果较差者 ,余 1例显像阴性 ,治疗效果好。 2例腺癌、1例鳞癌显像阴性 ,另 1例腺癌显像阳性。 2 4hT/N比值比 7～ 8h大。结论 99Tcm 2F7F(ab′) 2 显像阳性率高 ,无不良反应。
Objective To investigate the feasibility and safety of anti-small cell lung cancer monoclonal antibody 99Tcm 2F7F (ab ’) 2 in the diagnosis of lung cancer. Methods Twenty-eight patients with lung cancer underwent intravenous injection of 99Tcm 2F7F (ab ’) 2 1 ~ 2mg ~ 1 1 1 0MBq. Seven to eight hours later, the anteroposterior and posterior chest radiographs were performed and the plain images were obtained 24 hours later. The imaging results were compared with X-ray, and the count ratio (T / N)> 1 of lesions area and normal control area was positive. Results There were no adverse reactions in 18 patients from the end of injection to the end of imaging and the subsequent follow-up. Nine patients with untreated or undergoing chemotherapy for small cell lung cancer showed positive results. Chemotherapy over 10 days or multiple chemotherapies accounted for 5 cases, 4 cases were imaging positive, the clinical results were poor, and 1 case Negative imaging, the treatment effect is good. 2 cases of adenocarcinoma, 1 case of squamous cell carcinoma imaging negative, another case of adenocarcinoma imaging positive. 2 4hT / N ratio greater than 7 ~ 8h. Conclusions The positive rate of 99Tcm 2F7F (ab ’) 2 imaging is high without any adverse reaction.