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有关乙型肝炎表面抗原(HBsAg)慢性携带者发生急性病毒性肝炎的病例已有不少报道,通常认为是由于合并感染了其它类型的肝炎所造成,例如甲型、δ型或非甲非乙型肝炎,而由于原来的慢性肝炎恶化所致者刚一般认为可能性较少。美国国立卫生研究所在1978年7月～1984年4月,对150例慢性乙型肝炎病人进行了追踪观察。在2.4(0.5～5.5)年的平均随访期间内,有7例发生了急性黄疸性肝炎,出现疲乏、厌食、恶心和深色尿等急性症状,血清谷丙转氨酶突然急剧增高至正常值上限的25倍。经过检查,证实其中3例是由于感染了甲型肝炎病毒,另1例则感染了δ肝炎病毒。
There have been a number of reports of acute viral hepatitis associated with chronic carriers of hepatitis B surface antigen (HBsAg) and are generally thought to be due to coinfection with other types of hepatitis such as alpha, delta or non-beta Hepatitis, which is generally less likely due to the deterioration of the original chronic hepatitis. The National Institutes of Health conducted a follow-up study of 150 patients with chronic hepatitis B from July 1978 to April 1984. In the mean follow-up period of 2.4 years (0.5-5.5 years), acute hepatitis jaundice occurred in 7 patients with acute symptoms such as fatigue, anorexia, nausea and dark urine. The serum alanine aminotransferase suddenly increased sharply to the upper limit of normal 25 times. After examination, confirmed that three cases were due to hepatitis A virus infection, and the other was infected with hepatitis delta virus.