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本文报道1例用炎痛喜康治疗8周后产生急性间质性肾炎和微小病变型肾病综合征的患者。患者64岁,男性,严重的血清反应阳性类风湿关节炎,用阿司匹林、苏灵大、小剂量类固醇、青霉胺和血浆置换疗法治疗4年余,其间多次查肾功能和尿常规均正常。在入院前1年,患者一直服青霉胺(750mg/d)和阿司匹林。应用炎痛喜康8周后(20mg/d)即出现肾病综合征。尿蛋白量18.6g/24h,内生肌酐清除率35cm~3/min,遂停用青霉胺和炎痛喜康。经皮肾活检示光镜下肾小球正常、间质局灶淋巴细胞浸润、肾小管上皮细胞变平伴早期坏死、间质有
This article reports one case of patients with acute interstitial nephritis and minimal change nephrotic syndrome treated with piroxicam for 8 weeks. A 64-year-old man with severe seropositive rheumatoid arthritis was treated with aspirin, sulindac, low-dose steroids, penicillamine and plasma exchange for more than four years, during which time renal function and urinalysis were routinely checked . One year prior to admission, patients had been treated with penicillamine (750 mg / d) and aspirin. Nephrotic syndrome appears after 8 weeks of inflammatory pain (20 mg / d). Urine protein 18.6g / 24h, creatinine clearance rate of 35cm ~ 3 / min, then discontinued penicillamine and inflammatory pain Xikang. Percutaneous renal biopsy showed glomerular normal light microscope, interstitial focal lymphocyte infiltration, tubular epithelial cells flat with early necrosis, interstitial