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目的:探讨肝硬化患者的血浆降钙素基因相关肽(CGRP)水平的变化及其临床意义。方法:应用放射免疫分析法测定58例肝硬化患者(其中有腹水42例)和20名健康人的血浆CGRP水平并作对照。结果:肝硬化组血浆CGRP(57±23)ng/L显著高于对照组25±8)ng/L,<0.01;肝硬化组中有腹水者的血浆CGRP水平79±20)ng/L明显高于无腹水患者48±14)ng/L,<0.01;按肝功能ChildPugh分级,其C级的血浆CGRP水平高于B级,B级高于A级。线性相关分析显示,肝硬化患者的血浆CGRP水平与胆红素、凝血酶原时间无显著性相关,与白蛋白水平呈显著性负相关。结论:肝硬化患者血浆CGRP水平增高,其增高可能与肝功能损害和血流动力学紊乱有关。
Objective: To investigate the changes of plasma calcitonin gene related peptide (CGRP) level in cirrhotic patients and its clinical significance. Methods: Plasma CGRP levels were measured in 58 patients with cirrhosis (42 with ascites) and 20 healthy controls by radioimmunoassay. Results: The plasma levels of CGRP (57 ± 23) ng / L 肝 in cirrhotic patients were significantly higher than those in control subjects ±25 ± 8 ng / L , <0.01; those in cirrhotic patients with ascites 79 ± 20) ng / L was significantly higher than that of ascites 48 ± 14) ng / L, <0.01. According to Child-Pugh classification of liver function, the plasma CGRP level of C level was higher than that of B level and B level At A level. Linear correlation analysis showed that plasma CGRP levels in patients with cirrhosis and bilirubin, prothrombin time was not significantly correlated with the albumin level was significantly negatively correlated. Conclusions: Plasma CGRP levels are elevated in cirrhotic patients, which may be related to liver dysfunction and hemodynamic disturbances.