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目的探讨MSCT灌注成像对积水肾脏单肾功能的诊断价值方法8周龄以上成年健康雄性实验大白兔20只,制作右侧输尿管部分梗阻模型,分别在梗阻前、梗阻后4周行MSCT灌注扫描、单光子正电子发射计算机体层成像(SPECT)检查结果梗阻后4周MSCT灌注成像可见肾盂扩张,肾皮质明显变薄,皮、髓质血流量(BF)和血容量(BV)较梗阻前有明显下降(P<0.01),对比剂平均通过时间变化无统计学意义,肾皮质表面通透性(PS)有轻度下降趋势,但与梗阻前相比,无统计学意义,而肾髓质PS则较梗阻前有显著性降低(P<0.01)SPECT测定结果显示梗阻后右肾肾小球滤过率(GFR)均显著低于梗阻前(P<0.001),Tb显著延长(P<0.001),T1/2显著延长,无测定意义结论MSCT灌注技术对评价积水肾脏单肾功能具有一定的临床应用价值
Objective To investigate the value of MSCT perfusion imaging in diagnosis of hydronephrosis and renal single kidney function.Methods Twenty adult healthy male rabbits over 8 weeks old were selected to make the right ureteral obstruction model.All patients were divided into 4 groups: , Single photon positron emission computed tomography (SPECT) examination results 4 weeks after obstruction MSCT perfusion imaging shows dilated renal pelvis, renal cortical thinning, skin, medulla blood flow (BF) and blood volume (BV) than before obstruction (P <0.01). The average passage time of contrast medium had no statistical significance. The surface permeability of renal cortex (Mp) decreased slightly, but there was no significant difference compared with that before obstruction (P <0.01). The results of SPECT showed that the glomerular filtration rate (GFR) of right kidney after obstruction was significantly lower than that before obstruction (P <0.001) and Tb significantly prolonged (P < 0.001), T1 / 2 significantly prolonged, no measured significance Conclusion MSCT perfusion technique for evaluation of hydronephrosis kidney has a certain clinical value