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目的研究幽门螺杆菌阳性（Ｈｐ＋）不同胃粘膜病变的ＡｇＮＯＲ数量及ｒａｓｐ２１阳性表达率，探讨其生物学行为及Ｈｐ在此过程中可能的作用．方法经内窥镜病理检查证实胃粘膜病变（慢性浅表性胃炎、慢性萎缩性胃炎、肠上皮化生、异型增生、胃癌）共计２７８例．通过Ｈｐ检测（ＣＬＯｔｅｓｔ结合ＷａｒｔｈｉｎＳｔａｒｙ染色）证实其中１４６例阳性，１３２例阴性．分别对其粘膜标本作了ＡｇＮＯＲ定量及ｒａｓｐ２１表达的研究，比较不同胃粘膜病变中Ｈｐ阳性和阴性组间ＡｇＮＯＲ数目和ｒａｓｐ２１阳性表达率．结果除慢性浅表性胃炎外各病变中Ｈｐ＋组的ＡｇＮＯＲ数量均显著高于Ｈｐ－组（Ｐ＜００５或Ｐ＜００１）；除慢性浅表性胃炎及慢性萎缩性胃炎外各病变中Ｈｐ＋组的ｒａｓｐ２１阳性表达率均显著高于Ｈｐ－组（Ｐ＜００５）．结论Ｈｐ＋胃粘膜病变具有更多的肿瘤生物学行为，该菌可能刺激胃上皮细胞的过度增殖而启动恶性变．
Objective To study the number of AgNOR and the positive rate of rasp21 in Helicobacter pylori-positive (Hp+) different gastric mucosal lesions, and to explore their biological behaviors and the possible role of Hp in this process. Methods A total of 278 cases of gastric mucosal lesions (chronic superficial gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia, gastric cancer) were confirmed by endoscopic pathology. Hp detection (CLOtest combined with Warthin-Stary staining) confirmed that 146 cases were positive and 132 cases were negative. The AgNOR quantification and the expression of rasp21 were studied in the mucosa specimens. The number of AgNOR and the positive rate of rasp21 expression in different gastric mucosal lesions were compared between Hp positive and negative groups. Results In addition to chronic superficial gastritis, the number of AgNOR in the Hp+ group was significantly higher than that in the Hp-group (P<005 or P<001); except for chronic superficial gastritis and chronic atrophic gastritis The positive expression rate of rasp21 in the Hp+ group was significantly higher than that in the Hp-group (P<005). Conclusion Hp+ gastric mucosal lesions have more biological behaviors of tumors, which may stimulate the excessive proliferation of gastric epithelial cells and initiate malignant transformation.