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甲基三唑氯安定是一种新的苯二氮(艹卓)类衍生物。本研究证明这种化合物有明显的镇静作用和加强硫喷妥钠的催眠作用。它对摘除嗅系大鼠所致的各种异常行为均有明显的对抗作用,说明它有安定作用。该药对大鼠声源性发作,小鼠最大电休克发作和药物性惊厥均有对抗作用,为一广谱抗惊药。甲基三唑氯安定还有肌肉松弛作用和加强吗啡的镇痛效应。它的急性毒性很低,治疗指数大,安全范围宽,很有希望成为一个新的较好的镇静、催眠、安定和抗癫痫药。
Methyltriazolamide is a new benzodiazepine derivative. This study demonstrates that this compound has a significant sedative effect and potentiates the hypnotic effect of thiopental sodium. It has a significant antagonistic effect on various abnormal behaviors caused by the removal of olfactory rats, indicating that it has a stabilizing effect. The drug has a antagonistic effect on the onset of the sound source of the rats, the maximum electroshock attack in mice and the seizure of drugs, and is a broad spectrum anti-shock drug. Chlorothalone methyltridine also muscle relaxation and strengthening the analgesic effect of morphine. It has low acute toxicity, a large therapeutic index, and a wide range of safety, promising to be a new nicer sedative, hypnotic, tranquilizing and antiepileptic drug.