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目的探讨N-乙酰基转移酶(N-acetyltransferase,NAT)基因多态性与老年大肠癌易感性的关系。方法采用PCR-RFLP技术对105例年龄>60岁大肠癌患者(大肠癌组)和121例体检健康者(对照组)NAT基因多态性进行检测,分析NAT基因型分布特征。结果大肠癌组基因型Wt/M2频率(58.44%)明显高于对照组(23.41%)(P<0.01);2组慢速乙酰化基因型频率差异无统计学意义(P>0.05);吸烟组NAT快速乙酰化型个体患大肠癌风险(OR=1.959,95%CI:0.870～4.410)高于不吸烟组(OR=1.674,95%CI:0.830～3.378)。结论快速乙酰化基因型Wt/M2可能是老年大肠癌发病危险因素,NAT快速乙酰化基因型与吸烟有协同作用。
Objective To investigate the relationship between N-acetyltransferase (NAT) gene polymorphisms and susceptibility to colorectal cancer in elderly patients. Methods PCR-RFLP was used to detect NAT gene polymorphism in 105 patients with colorectal cancer (group of colorectal cancer) and 121 healthy controls (control group) aged >60 years, and analyzed the distribution characteristics of NAT genotypes. Results The frequency of genotype Wt/M2 in the colorectal cancer group was significantly higher than that in the control group (23.41%) (P<0.01); there was no significant difference in the frequency of slow acetylation between the two groups (P>0.05); The risk of colorectal cancer in individuals with rapid NAT group acetylation was higher (OR=1.959, 95%CI:0.870-4.410) than in non-smoking group (OR=1.674, 95%CI:0.830-3.378). Conclusion The rapid acetylation genotype Wt/M2 may be a risk factor for the development of colorectal cancer in elderly patients. NAT rapid acetylation genotype has a synergistic effect with smoking.