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【同义名】WDHA综合征、Verner-Morrison综合征、血管活性肠肽瘤、胰性霍乱。本征于1958年由Verner-Morrison首先报告。我国有散在病例报道。【病因】系由胰岛细胞瘤(其中50％以上为癌)中的D_1细胞或神经母细胞瘤分泌过量的血管活性液肽(VIP)所致。VIP可使胰液、胆汁及小肠液分泌大量增加,使前列腺素分泌亦增加。前列腺素可使肠平滑肌蠕动增强,并抑制肠粘膜对水与电解质的吸收,故引起严重腹泻。钾的排出比正常人增加5～20倍。此外VIP可抑制胃酸的分泌,故导致低胃酸。
[Synonym] WDHA syndrome, Verner-Morrison syndrome, vasoactive intestinal peptide tumor, pancreatic cholera. The original was first reported by Verner-Morrison in 1958. There are scattered cases in our country. Etiology is caused by excessive secretion of vasoactive peptide (VIP) by D-1 cells or neuroblastoma in islet cell tumors, of which more than 50% are cancerous. VIP can pancreatic juice, bile and small intestine fluid secretion increased, so that prostaglandin secretion also increased. Prostaglandin can increase peristalsis and inhibit the intestinal mucosa of water and electrolyte absorption, it caused serious diarrhea. Potassium excretion than the normal increase of 5 to 20 times. In addition VIP can inhibit the secretion of gastric acid, it led to low stomach acid.