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克拉维酸能抑制β-内酰胺酶活性而提高青霉素类抗菌活性。作者以替卡西林(ticarcillin)和克拉维酸(clayulanic acid)给11名健康志愿者,剂量分别为3.0g和0.2g,药后8小时内分别用微生物法监测外周淋巴液、血清和尿中药物浓度的改变。在药后0～1小时收集的淋巴液中替卡西林浓度的平均值为
Clavulanic acid can inhibit β-lactamase activity and improve penicillin antibacterial activity. The authors administered ticarcillin and clavulanic acid to 11 healthy volunteers at doses of 3.0 g and 0.2 g, respectively. Microbiological methods were used to monitor peripheral lymphatic fluid, serum and urine within 8 hours after drug administration Drug concentration changes. The average concentration of ticarcillin in lymph collected from 0 to 1 hour after drug treatment was