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观察２２例米非司酮配伍米索前列醇足月引产胎盘的病理形态学变化，并与４８例正常足月分娩的胎盘进行对比。结果：用药组引产胎盘可见：①胎盘绒毛数量减少，绒毛体积增大（Ｐ＜０．０１）；②绒毛间隙变窄（Ｐ＜０．０５）；③合体细胞结节及出芽增多（Ｐ＜０．０１）；④绒毛内毛细血管扩张，管腔内红细胞增多（Ｐ＜０．０１）；⑤电镜：微绒毛数量减少、变短、脱失，细胞核异染质加深，核固缩变性，粗面内质网扩张，线粒体肿胀。以上病理形态学改变与正常对照组比较均有显著差异。提示绒毛的这种缺血、缺氧改变与用药有关
Observe the morphological changes of 22 cases of mifepristone with misoprostol in full-term induced placenta and compared with 48 cases of normal full-term placenta delivery. Results: The abortion placenta of the treatment group showed that: ① The number of placenta villi decreased and the villus volume increased (P <0.01); ② The villus space narrowed (P <0.05); ③ The syncytiotrophoblast nodules and sprouting increased (P < (P <0.01); ⑤ electron microscopy: the number of microvilli reduced, shortened, lost, deepening of nuclear heterochromatin, nuclear pyknosis, Rough endoplasmic reticulum expansion, mitochondria swelling. The above pathological changes compared with the normal control group were significantly different. Prompt villus of this ischemia, hypoxia change and medication-related