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以放射免疫测定法（RIA），对生活在海拔2261米地区（西宁）和海拔3米地区（青岛）的成年wistar大鼠脑内β-内腓肽（β-EP）含量进行了比较研究。结果表明，垂体β-EP的含量与平原者对照组相比，下降非常显著（P＜0．01），皮层下降亦有显著性意义（P＜0．05），丘脑、桥延、纹状体均有所下降，但无统计学意义（P＞0．05）。提示，高海拔环境对大鼠各脑区β-EP含量有不同程度的影响。
The contents of β-endorphin (β-EP) in adult wistar rats living in 2261 meters above sea level (Xining) and 3 meters above sea level (Qingdao) were compared by radioimmunoassay (RIA). The results showed that the content of β-EP in the pituitary was significantly decreased compared with the control group (P <0.01), and the cortical decline was also significant (P <0.05). The content of β-EP in the hypothalamus, Body decreased, but not statistically significant (P> 0.05). Tip, high altitude environment of rat brain β-EP content varying degrees of influence.