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目的:建立新的复方酮康唑乳膏的含量测定方法。方法:改进提取方法,并将双波长紫外分光光度法和差示紫外分光光度法结合起来测定酮康唑含量。结果:得到标准曲线C(mg·L-1)=48.309ˉA-0.2464,(r=0.9999)。平均回收率为98.51%,RSD为1.24%。结论:该方法重现性好,操作简便,可用于复方酮康唑乳膏的质量控制。
Objective: To establish a new method for the determination of compound ketoconazole cream. Methods: The extraction method was improved. The combination of dual-wavelength ultraviolet spectrophotometry and differential ultraviolet spectrophotometry was used to determine the content of ketoconazole. Results: The standard curve C (mg · L-1) = 48.309 ˉ A-0.2464, (r = 0.9999). The average recovery was 98.51% with a RSD of 1.24%. Conclusion: This method has good reproducibility, easy operation and can be used for the quality control of compound ketoconazole cream.