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目的构建果蝇细胞周期调控的数学模型。方法使用一组常微分方程描述细胞周期网络中核心分子的相互作用,计算分子浓度的连续周期性变化,并捕获分子交互的离散事件。结果计算结果吻合实验观测到的分子浓度的周期变化,揭示和解释了细胞周期时程补偿的数学机制与定量特性。结论 E2F1(E2F transcription factor 1)所联结的正负反馈是调控G1/S与G2/M时程补偿的核心机制。
Objective To construct a mathematical model of Drosophila cell cycle regulation. The method uses a set of ordinary differential equations to describe the interactions of the core molecules in the cell cycle network, to calculate the continuous periodic changes in the concentration of molecules and to capture the discrete events of molecular interactions. The calculated results agree with the periodic changes of molecular concentration observed in the experiment, revealing and explaining the mathematical mechanism and quantitative properties of cell cycle time-history compensation. Conclusion The positive feedback and negative feedback associated with E2F1 (E2F transcription factor 1) are the core mechanisms regulating the time-history of G1 / S and G2 / M.