Both scientiic discovery and technological development are at some point faced with the question of how to progress from a trial-and-error approach to a highly controlled design process.In heterogeneous catalysis,the search for the optimal active site of a catalyst for a given chemical reaction has been the central objective of research for almost a century.In Both scientiic discovery and technological development are at some point faced with the question of how to progress from a trial-and-error approach to a highly controlled design process. In heterogeneous catalysis, the search for the optimal active site of a catalyst for a given chemical reaction has been the central objective of research for almost a century.In