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探讨慢性乙型病毒性肝炎(CHB)患者肝组织中,α-SMA的表达对肝脏炎性损伤和肝纤维化程度的病理诊断意义。采用免疫组化技术,观察12 7例CHB患者肝穿刺组织中α-SMA的表达,结果与现行病理诊断标准慢性肝炎分级、分期及Knodell-HAI评分系统进行统计学比较。另有6例作为对照,其中急性肝炎3例,静止性肝硬化3例。α-SMA在CHB、急性肝炎及静止性硬化三组中均有表达。主要定位在扩大的汇管区及其周围,以及小叶内点灶状坏死部位。且α-SMA表达与慢性肝炎病理分级(G)、分期(S)及Knodell-HAI评分呈显著正相关。α-SMA是判断慢性乙型肝炎肝损伤程度及纤维化程度的一个重要指标。
To investigate the significance of the expression of α-SMA in the pathological diagnosis of hepatic inflammatory injury and hepatic fibrosis in patients with chronic hepatitis B (CHB). Immunohistochemical technique was used to observe the expression of α-SMA in hepatic puncture tissue of 127 CHB patients. The results were compared with the current chronic hepatitis grading, staging and Knodell-HAI scoring system. Another 6 cases as a control, of which 3 cases of acute hepatitis, 3 cases of static cirrhosis. α-SMA in CHB, acute hepatitis and static sclerosis were expressed in all three groups. Mainly located in the enlarged portal area and its surroundings, as well as focal necrotic sites within the leaflets. The expression of α-SMA was positively correlated with pathological grading (G), stage (S) and Knodell-HAI score of chronic hepatitis. α-SMA is an important index to judge the degree of liver injury and fibrosis in chronic hepatitis B patients.