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目的研究不同性别、年龄患者亚临床甲状腺功能异常对血脂的影响。方法收集某院门诊就诊同时检测血脂、甲状腺功能患者的TC、TG、LDL-C、HDL-C、TSH、FT3、FT4数据,并进行统计学分析。结果共入选566例患者,平均年龄为62.37±16.85,男性占27.7%,女性占72.3%。研究人群的TC、LDL-C、TG、HDL-C平均血脂水平分别为4.86±1.35mmol/L、2.53±0.97mmol/L、1.28(0.91,1.85)mmol/L和1.36±0.33mmol/L。血脂异常率以高甘油三酯血症多见,占12%,其次为单纯高胆固醇血症占8.3%,混合型高脂血症占4.8%。亚临床甲状腺功能异常的TSH水平影响血TG水平(P=0.020),TSH水平越高,TG水平越高。而LDL-C、TC也随TSH升高呈现上升趋势(P>0.5)。同时,TSH水平还影响高胆固醇血症异常率(P=0.004),主要表现在重度亚临床甲减组高胆固醇血症异常率较轻度亚临床甲减组明显升高(28.6%vs 5.0%,P=0.010),同时明显高于甲功正常组(28.6%vs 7.4%,P=0.001)。结论亚临床甲状腺功能异常可对甘油三酯及胆固醇水平有一定影响。
Objective To study the effect of subclinical thyroid dysfunction on serum lipids in different gender and age. Methods The data of TC, TG, LDL-C, HDL-C, TSH, FT3 and FT4 in patients with thyroid dysfunction and thyroid function were collected at the outpatient clinic of a hospital and analyzed statistically. Results A total of 566 patients were selected, with an average age of 62.37 ± 16.85, 27.7% of men and 72.3% of women. The average levels of TC, LDL-C, TG and HDL-C in the study population were 4.86 ± 1.35mmol / L, 2.53 ± 0.97mmol / L, 1.28 (0.91,1.85) mmol / L and 1.36 ± 0.33mmol / L, respectively. The rate of dyslipidemia is more common in hypertriglyceridemia, accounting for 12%, followed by hypercholesterolemia 8.3%, mixed hyperlipidemia 4.8%. TSH levels in subclinical hypothyroidism affected blood TG levels (P = 0.020). The higher the TSH level, the higher the TG level. The LDL-C, TC with TSH increased upward trend (P> 0.5). At the same time, the TSH level also affected the abnormality rate of hypercholesterolemia (P = 0.004), which was mainly manifested in the abnormal subclinical hypothyroidism hypercholesterolemia than the mild subclinical hypothyroidism was significantly higher (28.6% vs 5.0% , P = 0.010), and significantly higher than the normal thyroid function group (28.6% vs 7.4%, P = 0.001). Conclusion Subclinical thyroid dysfunction may have some impact on triglyceride and cholesterol levels.