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目的：评价氨基末端B型利钠肽前体（NT-proBNP）在脓毒性休克患者早期预后评估中的价值。方法以2013年7月—2015年6月收住重症医学科入院诊断为脓毒性休克的47例患者为研究对象，入院后立即采用酶联免疫荧光法检测血浆NT-proBNP水平，按照28 d生存情况分为存活组（n=33）和死亡组（n=14），比较两组患者入院时血浆NT-proBNP水平的差异，并通过受试者工作曲线（ROC）评估入院时NT-proBNP水平与预后的关系。结果死亡组入院时NT-proBNP水平明显高于存活组，差异具有统计学意义（P＜0.05）。入院时NT-proBNP水平预测28 d病死率的曲线下面积（AUC）为0.714（95%CI：0.546～0.882）。结论血浆NT-proBNP水平可作为预测脓毒性休克患者预后的指标。“,”Objective To evaluate the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with septic shock.Methods A total of 47 patients with septic shock between July 2013 and June 2015 were enrolled. According to the situation of survival within 28 days from the admission, they were divided into survival group (n=33) and death group (n=14). Plasma levels of NT-proBNP were measured immediately after admission. The relationship between NT-proBNP levels and outcomes was determined by using receiver operating characteristic curve (ROC).ResultsThe plasma levels of NT-proBNP in death group were significantly higher than those in survival group (P<0.05). In the receiver operating characteristic curves for predicting 28-day mortality, the area under the curves (AUC) of NT-proBNP was 0.714 (95% confi dence interval [CI]: 0.546~0.882).Conclusion The plasma of NT-proBNP could be a useful prognostic biomarker for patients with septic shock.